Covalently-Linked Hyaluronan versus Acid Etched Titanium Dental Implants: A Crossover RCT in Humans

Biochemical modification of metal surfaces (BMTiS) entails immobilization of biomolecules to implant surfaces so as to induce specific host responses. This crossover irregular clinical test assesses clinical success and marginal bone biological process of dental implants bearing a surface molecular layer of covalently-linked hyaluronan as compared with management implants up to thirty six months when loading. Patients requiring bilateral implant rehabilitation received hyaluronan lined implants in one aspect of the mouth and ancient implants within the different aspect. 2 months when the primary surgery, a second surgery was undergone to uncover the screw and to position a healing abutment. when period of time, the operator proceeded with prosthetic procedures. Implants were evaluated by periapical radiographs and also the crestal bone level was recorded at medial and distal sites—at baseline and up to thirty six months. 100 and 6 implants were positioned, fifty two HY-coated, and forty eight controls were followed up. No variations were discovered in terms of insertion and stability, wound healing, implant success, and crestal bone biological process at any time thought-about. All interventions had associate degree best healing, and no adverse events were recorded. This trial shows, for the primary time, a victorious use in humans of biochemical-modified implants in routine clinical follow and in healthy patients and tissues with satisfactory outcomes.

Author(s): Saturnino Marco Lupi

Abstract | PDF

Share This Article