Coupling reactions involving aryldiazonium salt: Part-II. Chemoselective condensation with acetyl acetone and antibacterial activity

The aryldiazonium salt Ar-N2 Cl are highly reactive compounds. It is used as intermediate in different reactions. These reactions, either, losses nitrogen containing function or without loss of nitrogen function. First category includes replacement by -H, -OH, -Br, -F, -I, -CN, -NO2, aryl- etc. and the latter involves reduction and diazo coupling type reaction. In the present piece of work we have reacted the aryldiazonium salt with Active Methylene Group(AMG) containing compound, Pentane-2,4-dione or Acetyl acetone(AA). The final product formed has potential to use as precursor for synthesis of 4-methyl-3-acetylcinnoline or derivatives thereof. These compounds were tested for the antibacterial activity against gram negative bacteria, E. coli.

Author(s): C. J. Patil, Manisha C. Patil, Nilesh R. Pachpole and Vilas S. Waykole

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