Coupling reactions involving aryldiazonium salt: Part-I. Chemoselective condensation to synthesize 2-(phenylhydrazono)-3-oxo-butyricacid ethylester, its derivatives and their antibacterial activity

The aryldiazonium salt Ar-N2 ÅCl are highly reactive compounds. It is used as an intermediate in the different reactions. These reactions, either, losses nitrogen containing function or without loss of nitrogen function. First category includes replacement by H, -OH, -Br, -F, -I, -CN, -NO2, Aryl- etc. and the latter involves reduction and diazo coupling type reaction. In the present piece of work we have coupled the aryldiazonium salt with active methylene group(AMG) bearing moiety, b-keto ester viz. Ethyl acetoacetate(EAA). The final product formed has potential to use in some organic reaction to prepare derivatives of benzodiazepines. These compounds were tested for the antibacterial activity against E. coli when compared with ampicillin as standard drug.

Author(s): C. J. Patil, Pooja A. Patil, Pravin B. Patil and Manisha C. Patil

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