Controlled release from bisoprolol fumarate buccal patches

The aim of the present work is to investigate the formulation of Bisoprolol Fumarate buccal patches for controlled release medication in order to treat blood pressure and cardiac diseases. The half life of Bisoprolol Fumarate is 10 hrs and Bisoprolol fumarate is acid labile, in order to treat the angina pectoris which required 24hr controlled drug release and to avoid degradation of drug in GIT, the buccal patches were prepared. The patches were prepared by solvent casting method using hydroxyl propyl methyl cellulose (HPMC K15) and Carbopol 974. The patches were found to be smooth in appearance, uniform in thickness, weight uniformity, drug content, swelling index, folding endurance, surface pH and in vitro diffusion study using Keshery chien diffusion cell. The optimized patch of 1% HPMC K15 exhibit in vitro release of 80% through cellophane membrane and in vivo release 73.4% through egg membrane and the optimized patch of 1% Carbopol 974 exhibit in vitro release of 75.2% through cellophane membrane and in vivo release 71.1% through egg membrane in 8 hrs showing good mucoadhesive strength and mucoadhesive time.

Author(s): Yashwant T. Dangat, Nilesh A. Bari, Swati C. Jagdale, Aniruddha R. Chabukswar and Bhanudas S. Kuchekar

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