Conditional gene targeting using UCP1-Cre mice directly targets the central nervous system

Adipose tissues maintain systemic energy homeostasis through the storage and release of lipids and adipokines and contribute to whole-body metabolic rate Within adipose tissues, there are at least three different types of adipocytes: white, beige/brite, and brown. White adipocytes have a unilocular appearance and function to store energy. In contrast, brown adipocytes dissipate energy as heat through a process known as adaptive thermogenesis and histologically have a multilocular phenotype. Brown adipocytes produce heat by utilizing glucose and lipids, which results in increased energy expenditure. This is accomplished by uncoupling protein 1 (UCP1), a protein localized to the mitochondrial inner membrane which uncouples proton transport across the inner mitochondrial membrane from the electron transport chain, leading to release of chemical energy as heat Beige or brite (brown in white) adipocytes phenotypically appear like white adipocytes, but when activated, they have the capacity to increase UCP1 expression and thermogenesis and obtain a multilocular appearance

Author(s): Matthew J. Potthoff

Abstract | Full-Text | PDF

Share This Article