Complexation of Ni and VO metals with bidentate schiff base derived from Sulfamethoxazole drug

Schiff bases and their complexes are widely studied owing to their increasing role in biological systems. Schiff bases derived from sulfa drugs act as good ligand to transition metal ions and they exhibit several coordination modes. The metal complexes of Ni(II) and VO(II) have been synthesized with Schiff base of sulfamethoxazole [4-amino-N- (5-methyl-3-isoxazolyl) benzenesulfonamide] and salicylaldehyde. Sulfa drugs concentrate in the urine before being excreted and treat urinary tract infections. Conductometric titrations have suggested metal-ligand ratio of 1:2 for both Ni(II) and VO(II) complexes. The ligand behaves as a bidentate with N, O donor atoms. Complexes have been synthesized and characterized by elemental analysis, IR and UV-Visible spectral studies.

Author(s): Shrikant Sharma, Neha Sharma, Bharti Jain and Suman Malik

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