Comparison of Different Adrenergic Blockers on Cutaneous Wound Healing in Wistar rats

Background: This study was undertaken to evaluate & compare the effect of nonselective β-blocker, α-blocker and α+β blocker on excision wounds in animal models. Methods: Animals with excision wound models were divided into six groups (n=6) and were administered vehicle, propranolol 1% , propranolol 2%, carvidelol 2%, carvidelol 5% and phentolamine 2% ointments topically respectively daily for 21 days. Contraction was noted every alternate day and wound area was determined. Wound contraction (WC) was also calculated. Results: Carvedilol 5%, propranolol 1% and propranolol 2% significantly increased percentage of wound contraction (p ≤ 0.05) as compared to phentolamine. In comparison to carvedilol 5%, propranolol 1% was superior. Conclusion: β-blocker are superior to α- blockers in the process of wound healing.

Author(s): Veena Nayak, Bharti Chogtu, Manohar R Amaresh Parimi, Anil K Mahapatra & Rajdip L Vaishnav

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