Comparative Study of Central Nervous System Effect of Santalum album Linn. Paste Fragrance v/s Aqueous Extract in Wistar Albino Rats

This study was designed to investigate the difference in CNS effects of Santalum album L. administered via oral route and inhalational route. The aqueous extract (4 ml) and fragrance of paste was administered to rats for continuous period of 7 days. The pharmacological activities assessed were spontaneous behaviour using autotrack instrument and analgesic activity using hot plate analgesia meter. Diazepam (4mg/kg) and Pentazocine (5 mg/kg) served as standard drugs. Statistical analysis of the obtained results was carried using one way ANOVA followed by Dunnett’s test. Both the extracts expressed significant sedative action as indicated by reduction in mobility of rats as compared to control groups. The aqueous extract produced better sedation and the effect was seen to be cumulative. Analgesic effect was not clear from the obtained results.
It can be concluded from the study that Santalum album Linn. administered by oral route had more prominent central nervous system effect.

Author(s): Madhusudan P Joshi, Sneha R Satarkar, Vedita Hegde Desai

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