Comparative Phytochemical and Pharmacological Evaluation of flowers of Plumeria rubra L. f. rubra and Plumeria rubra f. lutea

hade dried flowers of Plumeria rubra f. rubra and Plumeria rubra f. lutea were subjected to successive solvent extraction by soxhlation using n-hexane, chloroform, ethyl acetate and methanol. The extracts were subjected to preliminary phytochemical screening using standard procedures and the data obtained from the flowers of both the species was comparatively evaluated. The methanolic extracts, rich in phytochemical constituents, were screened for analgesic activity (acetic acid-induced writhing & tail immersion methods) using diclofenac (10mg/kg b.w) as standard and antipyretic activity (brewer’s yeast-induced pyrexia test) using paracetamol (100mg/kg; p.o.) as standard at dose levels of 250 and 500 mg/kg b.w. Oral administration of methanolic extracts of Plumeria rubra f. rubra and Plumeria rubra f. lutea (MEPR & MEPL) produced significant reduction in number of writhes induced by acetic-acid. Moreover, in tail immersion, MEPR & MEPL significantly raised the pain threshold at different time intervals, in comparison with control. There was a significant dose-dependent inhibition in both the methods. In antipyretic activity, MEPR & MEPL significantly reduced hyperthermia at either dose levels. The results obtained in all the animal models were highly significant and comparable to that of standard drugs. Hence, from the above findings, it can be concluded that Plumeria rubra possesses potent analgesic and moderate antipyretic properties. However the methanolic extract of flowers of Plumeria rubra f. rubra was found to be more potent than that of Plumeria rubra f. lutea flower extract

Author(s): Kalam Sirisha, Yegnambhatla Rajendra, Periyasamy Gomathi, Meesa Madhavi, Guggulothu Hima bindu and Yegnambhatla Aparna

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