Clinical Evsaluation of Short Term Regieme in Management of Pulmonary Kochs

Declining nutritional and economic status poses increased threat of Koch’s lesion even among middle class family. Considering the cost of Anti tuberculosis treatment, high disease endemicity due to emergence of resistant strain of mycobacterium tuberculosis and hepatotoxicity of currently used Rifampicin, Pyrizinamide and Ethambutol, A safe drug combination is a need of the time. Hence a drug regime constituting Levofloxacin 500mg and Isoniazide 300mg was evaluated in pulmonary tuberculosis . Objective: To short out safe potent short term anti tuberculosis regime, improved treatment for drug resistant cases and provide effective schedule to check endemicity and insure natural lung repair to secure normal lung’s vitality. Material method: 156 clinicopathologically and radiologically established cases of Pulmonary tuberculosis were put on the trial regime, with high protein diet. Each patients were duly evaluated for pre and post vital capacity of lung, hematological, hepatic and renal status. Result: reveals early sputum conversion, resolution or alleviation of presenting features, improvement in appetite, weight gain with limitation of sputum infectivity and disease communicability in 60±5 days, weight gain of6±2kg ,non recurrence or relapse of the disease in 1 yr post therapy follow up, improved lung vitality , body physique and 100% drug compliance with complete safety profile(Hemato, hepato renal function) Conclusion: This regime show complete relief of clinical presentation with clinicopathological and radiological cure in all the cases without any adversity or relapse.

Author(s): Avinash Shankar, Abhishek Shankar, Shubham, Amresh Shankar and Anuradha Shankar

Abstract | PDF

Share This Article