Chitosan encapsulated curcumin loaded zinc ferrite core shell nanoassembly for biocompatible drug delivery on chicken embryonic stem cells

Present work report the biocompatibility study of a nanoassembly of the drug Curcumin conjugated with Zinc Ferrite core and encapsulated by functionalizing agent Chitosan. Zinc Ferrite nanoparticles were synthesized separately by combustion route using urea and glycine mixture as fuel, and these nanoparticles were characterized on the basis of Transmission Electron Microscopy, FTIR spectra and X-Ray Diffraction. The average crystallite size of the ferrite nanoparticles were found to be 42 nm. The Chitosan capped and CTAB stabilized Curcumin loaded Zinc Ferrite Core shell CCZ nanoassembly were synthesized by In Situ Co precipitation. The mean particle size of these bioactive material was found to be 52nm. Slight cubical and spherical morphology of these nanostructure was estimated using Transmission Electron Microscopy , X ray Diffraction, and SEM. The formation of nanostructure was confirmed by UV-VIS, FTIR and Fluorescence spectra measurements. The drug delivery ability and biocompatibility on stem cells with plausible cancer therapy applications of these nanoassembly were elaborated on the basis in vitro test performed on Chicken Embryo Stem cells. The material had exhibited dose and time dependant biocompatibility with LD50 of 5 ng./ml. The internalization of Curcumin in the Stem cells elaborated on the basis of microscopic images. These functionalized nanoassembly had exhibited prominent applications in clinical trials for anticancer treatments

Author(s): V. J. Sawant1, S. R. Bamane1 and S. M. Pachchapurkar2

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