Characterization and evaluation of Clarithromycin Hydrophilic floating matrix tablets

Present investigation describes the preparation of Clarithromycin hydrophilic matrix tablets by direct compression technique followed by in vitro floating characterization statistically. The floating hydrophilic matrix tablets prepared by using different grades of polymer (HPMC) of varying concentrations, different concentration of sodium bicarbonate and varying ratios of MCC. Floating properties such as FLT, TFT, and Swelling index. Tablet hardness had found to be affecting on floating behavior. Hydrophilic matrix floating tablets of Clarithromycin were developed to increase the gastric residence time which leads to increased bioavailability by giving sufficient time to release the drug in GI tract.

Author(s): Balkrushna K. Patel, Sridhar Bhople, Paresh A. Prajapati and Paresh U. Patel

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