Aphthous ulcer is typically a recurrent round or oval sore or ulcer inside the mouth on an area where the skin is not tightly bound to the underlying bone, such as on the inside of the lips and cheeks or underneath the tongue. Affecting as many as 25% of the population worldwide with aphthous ulcer. There may be female predominance in some adult and child patient. We report a case of a 10-years old female child patient presented a 1-year history of episodes of multiple recurrent ulcers on lips,cheeks and tongue. Topical application of Amlexanox 5% oral paste and Iron tablet( combination of Iron (III) hydroxide polymaltose complex INN 188mg equivalent to 47mg elemental iron, folic acid BP 0.5mg and zinc sulphate monohydrate USP 61.8mg) and vitamin C was given. Also focused on improvement of balanced diet and proper oral hygiene maintain. As a result improvement of pain, discomfort and healing of the aphthous ulcer. No side effects were recorded.