Pleural Aspergillosis is a rare entity, with most of the cases occurring on a background of lung disease or surgery. We report a case of a 52-year-female who developed pleural Aspergillosis. Patient presented with dyspnoea and weight loss of 6 weeks duration. A chest radiograph revealed features of the pleural effusion with lung collapse. Histopathology evaluation confirmed Aspergillus. We report this case in view of the extreme rarity of pleural Aspergillosis occurring in a setting of previous breast carcinoma.