Black Urine: A Tale of Two Ages

Alkaptonuria is a rare inborn error of metabolism with autosomal recessive inheritance with a mutation in homogentisate 1,2-di oxygenase. It results in excessive excretion of homogentisic acid in the urine, ochronosis, and debilitating arthritis of the spine and large joints. In this report 25-year male presented with darkening of urine and under garments. Lab findings are compatible with the diagnosis of Alkaptonuria. Treatment was initiated and patient is on follow up.

Author(s): Shanmuganathan Velu, Arul Rajagopalan, Manorajan Rajendran, Jegan Arunachalam, Arun Prasath, Rakesh Durai, Benoy Varghese, Niranjan Raja and Shiva Kumar Ammayappan

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