Biosome forming matrices of glibenclamide: Effect of soya lecithin: Stearyl alcohol ratio on in vitro release

Neelkant Prasad

Abstract

Biosome forming matrices of glibenclamide: Effect of soya lecithin: Stearyl alcohol ratio on in vitro release

A lipid carrier system for oral hypoglycaemic agent glibenclamide comprising of two lipid components chosen from classes of different polarity wherein one of the lipid components is amphiphatic, bilayer forming and the other is non polar. Discrete lipid particles were formed spontaneously when introduced into aqueous medium without any physical or chemical treatment or initiation. The spherical lipid bilayers thus formed in vivo are referred to as biosomes and the lipid matrix is referred to as biosome forming matrix.

Author(s): Neelkant Prasad

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