Biological Screening of Plants Extract Showing Hypoglycaemic and Wound Healing Properties: Capparis zeylanica and Primula denticulata.

Primula denticulata belonging to family Primulaceae and Capparis zeylanica to Capparidaceae. P. denticulata is commonly known as drumstick primula and grow in shady places and open slopes. Similarly, C. zeylanica is commonly known as Indian creeper, a climbing shrub. The literature survey revealed that there is no experimental evidence of antidiabetic and wound healing effect of the plants. The present investigation was planned to evaluate the hypoglycaemic and wound healing properties in plants extract. In the hypoglycaemic activity, the animals were examined up to 21 days, in which Streptozotocin (STZ) was used as diabetes inducer and Glipizide as a standard. For wound healing activity, excision-wound model was used and 1% Silver Sulphadiazine ointment was used as standard. The dose 200 mg/kg body weight was selected from both ethanolic (EtOH) and aqueous extract for hypoglycaemic activity. For hypoglycaemic activity, the result of aqueous extract of C. zeylanica (200.3±3.24**) and EtOH extract of P. denticulata (203.8±2.30**) have shown a good reduction in blood glucose level and compared with normal control. 5% ointment formulation of EtOH extract of C. zeylanica and P. denticulata have been shown 98.36% and 93.08% wound healing contraction at day18 respectively when compared with normal control. Finally the results concluded that, both the plant extract have probable source of hypoglycaemic and wound healing property from natural origin.

Author(s): Sanjay Singh, Sadath Ali and Mamta Singh

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