Biological activity of bis(nicotinohydroxamato) oxidovanadium(IV) complex

The oxidovanadium(IV) hydroxamate complex of composition [VO(C5H4NCONHO)2] has been synthesized by the reaction of VOSO4.5H2O with two equivalents of potassium salts of nicotinohydroxamic acid in aqueous methanol medium. The complex has been characterized by elemental analyses, molar conductivity, magnetic moment measurements, electrochemical and IR, UV-Vis spectral and mass spectrometric studies. Based upon spectral studies, a square-pyramidal geometry around vanadium has tentatively been proposed for complex. The antimicrobial potential of complex has been assayed against some pathogenic bacteria E. coli, S. aureus, S. typhi, S. paratyphi, S. epidermidis, K. pneumoniae and fungi C. albicans, B. fulva and F. oxysporum by minimum inhibitory concentration method. The complex has been found to possess promising antimicrobial potential relative to ligands. Thermal behavior of complex has been studied by TG-DTA techniques. The coordination compounds of complex with 2-cyanopyridine and 4-aminobenzonitrile have also been synthesized and characterized by physicochemical and IR spectral technique. Cytotoxicity of complex was assayed on mammalian transformed cell line Hep2c, by MTT assay

Author(s): Sonika Sharma and Neeraj Sharma

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