Behaviour of male Wistar rats in response to different doses of extract of Isoberlinia doka

The present study investigated the effects of different doses of stem-bark extracts of Isoberlinia doka (I.D) on neuromuscular and sensorimotor responses of 35 male Wistar rats. The results of the study showed that oral administration of the extract at 200 and 600mg/Kg body weight did not elicit any significant (P > 0.05) change in neuromuscular and sensorimotor responses of male Wistar rats. However, the administration of the extract at doses of 1000, 1400, 1800 and 2200mg/Kg body weight significantly (P < 0.05) decreased the neuromuscular and sensorimotor responses of the rats. In conclusion, the present study, for the first time, showed that higher doses of I.D above 600mg/kg body weight inhibited neuromuscular and sensorimotor pathways, which have resulted to the impairment of postural stability, skill performance, motor strength, placing and righting reflex responses. Thus, the administration of extract of I.D by individuals should be done with great caution.

Author(s): Adeiza A.Abubakar, Minka N.Salka* and Fatima B.Hassan

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