Antisense Technology: Oligonucleotides and its Delivery Strategies

Aim: The present study highlights antisense technology where oligonucleotides have predominant role in its delivery for various diseases. Objective: Antisense compounds are biological molecules consisting of small ribonucleic acid (RNA) or deoxyribonucleic acid (DNA) segments (Oligonucleotide) which have enormous potential for the treatment of number of diseases. Methods: All the methods analyzed were obtained through high impact articles. Results: Several impediments were made to Oligonucleotide for its widespread usage as them as drugs to overcome their lack of stability in physiological fluids and their poor penetration into cells. Experiments like, association with or encapsulation within nano-and micro sized drug delivery systems, lipids and polymers could help to increase the efficiency of oligonucleotide delivery. This review discusses the use of cationic lipids, Cell penetrating peptides, nanoparticles, microparticles and several novel methods that have recently been explored as delivery vehicles. Conclusion: The use of naked Oligonucleotide given a clear cut way to new targets for potential therapeutic compounds. Apart this, antisense therapy represents a promising and evolving approach to the management of numerous diseases in which a specific abnormality has been identified as a primary or major contributing etiologic factor. In near future, authors strongly believe that antisense therapy will give a positive way for number of In vitro experiments and break through for many life threatening diseases.

Author(s): V Lavakumar, DVR Saigopal, C Sowmya, N Venkateshan, S Janardhan, M Niranjan Babu

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