Antioxidant impacts of tocotrienols on copper-mediated in-vitro oxidative modification of low density lipoprotein in normal and type II diabetic patients

Cardiovascular diseases (CVD) are the main cause of disability and premature dead worldwide. Epidemiological studies have suggested a link between atherosclerosis and diabetes. Atherosclerosis is a multifaceted diseases process with several different well defined risks factors, such as hypercholesterolemia, hypertension and diabetes. In this study we investigated the efficacy of antioxidant agent , tocotrienols (T3) by analyzing all the parameters in plasma, TC, VLDL-C, LDL-C, HDL-C, HDL2-C, HDL3-C, LDL-P, HDL-P, VLDL-P, TBARS, MDA and in vitro oxidizability of LDL in absence and presence of tocotrienols on normal and Type II diabetic patients. In this study, The in-vitro impact of tocotrienols on Total Antioxidant Power of the plasma for the normal & diabetic individual before and after the treatment have shown results similar to the ones expected. On comparing the TAP for plasma without tocotrienols in Normal & Diabetic patients showed decrease for the Diabetic values. Similarly TAP for plasma without tocotrienols in Normal & Diabetic patients shows increase in value compared to individuals control condition as well as between them. Thus, it clearly denotes that tocotrienol is capable of showing the antioxidant properly to give promising results. On the other hand, Tocotrienols treatment significantly blocked the increase in plasma Conjugated Diene formation and MDA to a level close to corresponding normal values. In conclusion, Tocotrienols mediated multiple therapeutic benefits described in this study supports that daily intake of T3 as dietary supplement by DM maybe useful in the prevention and treatment of DM including hyperlipidemia and atherosclerosis. In addition, daily intake of dietary tocotrienols will be efficacious and cost efective and a good source of Vitamin E.

Author(s): Amir Khan1, Fouzia Ishaq2, Munish Thakur3 and Manoj Kumar4

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