Antinociceptive activity of methanolic extract of leaves of Vitis vinifera

Vitis vinifera (Vitaceae) is traditionally used to treat some painful conditions. Purpose of the present study was to evaluate antinociceptive activity of methanolic extract of leaves of Vitis vinifera (MELV) and also its possible mechanism of action. Antinociceptive activity of MELV was evaluated in writhing, hot plate, tail flick and formalin models in mice (n = 6). To elucidate the mechanism of action, animals were pre-treated with opioid antagonist, naloxone (5 mg/kg) and muscarinic antagonist, atropine (5mg/kg) and subjected to hot plate test. Oral administration of MELV exhibited significant (p<0.05) antinociceptive activity in a dose dependent manner in writhing, hot plate, tail flick, and formalin models. Pre-treatment with atropine did not cause any change in antinociceptive activity of MELV, while, pre-treatment with naloxone significantly (p < 0.05) diminished the MELV antinociceptive activity in hot plate test. The MELV exhibits opioid-mediated antinociceptive activity at the peripheral and central levels, which supported the traditional use of the Vitis vinifera in the treatment of some painful diseases.

Author(s): Bodka Sadaiah, K. T. Sunil Kumar, CH. N. Kavitha, S. Manohar Babu and V. Prabhakar Reddy

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