Antimotility and antisecretory effect of Kutajarishta: An ayurvedic antidiarrhoeal formulation

Antidiarrhoeal effect of Kutajarishta, an ayurvedic formulation was evaluated in castor oil and magnesium sulphate induced diarrhoea in mice. Effect of Kutajarishta was also studied on intestinal propulsive movement and intestinal fluid accumulation in mice. Kutajarishta showed antidiarrhoeal activity against castor oil and magnesium sulphate induced diarrhoea in mice. It has produced a significant decrease in the frequency of defecation and severity of diarrhoea. The % inhibition of diarrhoea in castor oil treated animals were 48.54 %, 71.27 %, 86.36 % and 92.45 % for Kutajarishta 2.5, 5, 10 ml/kg dose (p.o.) and Loperamide (standard) 2 mg/kg dose (p.o.) respectively. The % inhibition of diarrhoea in magnesium sulphate treated animals were 50.98 %, 73.52 %, 85.78 % and 91.11% for Kutajarishta 2.5, 5, 10 ml/kg dose (p.o.) and Loperamide (standard) 2 mg/kg dose (p.o.) respectively. Kutajarishta produced significant reduction in the intestinal transit in mice. The mean peristaltic index (%) for Kutajarishta 2.5, 5, 10 ml/kg dose (p.o.) and Atropine sulphate (standard) 5 mg/kg dose (i.p.) were 15.87 %, 27.33 %, 40.28 % and 55.94 % respectively. Kutajarishta significantly reduced intraluminal fluid accumulation. The % inhibition of intestinal fluid accumulation for Kutajarishta 2.5, 5, 10 ml/kg dose (p.o.) and Chlorpromazine (standard) 30 mg/kg dose (p.o.) were 45.54 %, 63.76 %, 76.23 % and 89.50 % respectively. The results obtained suggest that Kutajarishta produces antidiarrhoeal effect through its antisecretory and antimotility effect. Preliminary phytochemical analysis revealed the presence of carbohydrates and alkaloids as major constituents.

Author(s): Prashant B. Shamkuwar and Sadhana R. Shahi

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