Antimicrobial Photodynamic Therapy for S. Pyogenes Eradication

Antimicrobial photodynamic treatment (aPDT) kills bacteria across the prokaryotic spectrum by combining a photosensitive chemical with an activating light source. High amounts of oxidative stress exerted on bacteria membranes cause disinfection, resulting in fast mortality without genomic exposure and subsequent induction of resistance. The electrostatic interaction between cationic photosensitizers and generally anionic bacteria membranes causes specificity, which is a side effect of soft tissue diseases like necrotizing fasciitis. The goal of this investigation was to see if the bacterium was susceptible to aPDT in both planktonic and biofilm cultures, as a prelude to using it in human clinical trials.

Author(s): J Cross, C Romo*, R Andersen and N Loebel

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