Antileishmanial, cytotoxic, antioxidant activities and phytochemical analysis of Rhazya stricta Decne leaves extracts and its fractions

The aim of the present investigation deals with biological evaluation of Rhazya stricta Decne leaves. For these purpose different biological assays of crude methanolic extract (CME) and its fractions that are chloroform fraction, n-hexane fraction, acetone fraction and aqueous fraction were carried out. The results of CME showed maximum Antileishmanial activity with ED50 14.93 μg//ml, while the ACE showed significant Cytotoxic activity with ED50 value 1.54 μg//ml. Antioxidant analysis of CME determined the IC50 values 36.599 μg//ml. Furthermore, the Phytochemical analysis of CME and its fractions showed the presence of Alkaloids, Flavonoids, Phenols, Saponins and Diterpenes. The extract and fractions were also appreciating for further investigations in future.

Author(s): Muhammad Javed Khan, Nizam.U.Baloch, Sajid Nabi, Nisar Ahmed, Zahoor Bazai, Masoom Yasinzai and Yasser. M. S. A. Al-Kahraman*

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