Anti-Inflammatory, Proton Pump Inhibitor and Synthesis of Some New Benzimidazole Derivatives

A series of novel of 1 and 2-substituted benzimidazoles was synthesized by the reaction of Phenelenediamine with p-hydroxybenzaldehyde. All the synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, and elemental analysis. The newly benzimidazoles derivatives were screened for analgesic and anti-inflammatory activities on carrageenan induced paw oedema in rats. Among all the benzimidazol derivatives, compound 8b and 10 exhibited significant analgesic and anti-inflammatory activities. Acute ulcerogenicity studies showed that compound 6 did not cause any gastric mucosal lesions in the rat stomach at the dose (300 mg/kg) indicating that this compound is devoid of gastric irritant properties.

Author(s): Rezk R Ayyad, Helmi M Sakr, Kamal M El-Gamal, Ibrahim H Eissa, Ahmad HA Tita, Adel S Abd El-Raheim, Farag F Sherbini, Ahmad M Mansour

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