Anti-inflammatory Effects of Kelussia odoratissima in Rats Model of Rheumatoid Arthritis

Background and Purpose
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of the joints and other body organs, which 1 % of the human population is affected. RA induced in the fourth and fifth decades of life and in women is more common. Kelussiao doratissima contains compounds such as flavonoids, mainly aggregated in the inflorescence and stems of Kelussia, has anti-inflammatory effects. Present study aimed to investigate the anti-inflammatory effect of Kelussia odoratissima on rheumatoid arthritis induced in Wistar rats.
Materials and Methods
A total of 30 female Wistar rats using subcutaneous injection of complete Freund's adjuvant has been induced and were randomly divided into five groups containing negative control (no treatment), positive control (receiving indomethacin (3mg/ Kg) and three rheumatoid arthritis group receiving three different doses (100,200and 300mg/kg) of hydroalcoholic Kelussia odoratissima extract. material injection were tested in the animals for 10 days. The symptomsof Rheumatoid arthritis were evaluated according to standardized scoring method at paw and double-blind for the different categories daily. CRP levels were measured and Data were analyzed using the SPSS statistical program (version 17 for Windows). In all the cases for comparison between different groups, Mann-Whitney U-test was used.
Results
The symptoms indicating disease severity was observed in the treated group compared to the negative control so that decreasing trend in disease severity in the group receiving300 mg / kg of Kelussia extract was significant However these verity of the disease was increasingly in the negative control. Serum CRP levels in groups () were significantly decreased.
Conclusions
Kelussia odortissima has a anti-inflammatory effects and can reduce the inflammation and morbidity in rheumatoid arthritis. Thusit can be used as a drug for reducing and controlling inflammation in Rheumatoid arthritis.

Author(s): Yousefzadeh Zahra, Karimi Akbar

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