Anti-inflammatory effect of lycopene rich paste extract in the presence of NSAID on carrageenan induced paw oedema

Immense interest in nutraceuticals and their potential benefits has created the need to review the existing scientific information on their effect in preventing and managing inflammation that accompanies most chronic diseases. This study focuses on the basic mechanisms of inflammation and the potential of nutraceutical lycopene against the carrageenan induced oedema. The nutraceutical lycopene, when tested against carrageenan induced paw oedema showed significant anti-inflammatory activity in a dose dependent manner along with test drug. The nutraceutical at the dose of 5,50 and 100 mg in combination with test drug at 5 mg/kg b. wt exhibited appreciable results and decreases the % swelling from 94.45% to 68%, 45% and 25% respectively. At the same dosage level, the MDA was decreased to 4.88, 4.07 and 3.77nmol/mg protein from Carrageenan induced rats (7.99nmol/mg protein). In addition, nutraceuticals along with the test drug increases the glutathione levels from 3.33 to 5.76, 6.01 and 7.98μg GSH/mg protein at the concentration of 5, 50 and 100mg/kg b wt.

Author(s): Sabuhi Zargar, Showkat Ahmad Ganie, Akbar Masood and Mohammad Afzal Zargar*

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