Anti-inflammatory and analgesic activity of various fractions of Vetiveria zezanioides (V.Z.) in rodents

Vetiveria zizaniodes (Vetiver) is commonly known for its effectiveness in soil and sediment erosion control. It can tolerate to extreme soil conditions and produce a high biomass even growing in contaminated areas. Vetiver oil has been also used in the treatment of several diseases, including mouth ulcers, fever, headache, inflammation and gastritis. The anti-inflammatory activity was evaluated by carrageenan induced paw oedema and cotton pellet induced granuloma in rats. The analgesic activity was carried out by using acetic acid induced writhing reaction in mice and tail immersion method. Four fractions (n-hexane, chloroform, ethyl acetate and butanol) of V.Z. at a dose 200 mg/kg, p.o. Were tested. In carrageenan induced paw oedema and cotton pellet induced granuloma animal model, the ethyl acetate and chloroform fraction of V.Z. were found to be more significant (p< 0.01) and also in acetic acid induced writhing reaction in mice. The n-hexane fraction along with ethyl acetate and chloroform fraction showed significant (p< 0.01) increase in reaction time in tail immersion method. The results were further substantiated by biochemical findings, suppressing free radicals, GSH and catalase levels in blood. The V.Z. significantly showed anti-inflammatory and analgesic effect through its anti-oxidant potential

Author(s): Kamble Rahul D*, Rodge Kishor N, Maske Kanchan S and Shaikh Haidarali M

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