Anti-Inflammatory Activity of Quercetin in Acute and Chronic Phases of Inflammation in Guinea Pigs

Objective: To evaluate the anti-inflammatory activity of flavonoid (Quercetin 20 mg/kg) on acute inflammation (carrageenan-induced paw edema) and chronic inflammation (cotton pellet granuloma) in guinea pigs.
Methodology: Studying sample of guinea pigs were divided in two groups. Group I was used as control received 1ml of 5% carboxymethyl cellulose suspension, group II was treated with indomethacin (10 mg/kg) and Quercetin at a dose of 20 mg/kg was given orally to group III. 1.0 ml of carrageenan was injected s.c. to plantar region of right hind paw of each pig. The change in paw volume was measured at 0, 1, 2, 3 and 4 hours intervals. For chronic model of inflammation, sterilized cotton pellets weighing 50 ± 1mg each, were implanted into both sides of the groin region of each pig, under light anesthesia. Drug treatment was given for 7 days. On the eight day, cotton pellets along with granuloma were removed surgically and wet pellets were weighed, after that dried at 600C overnight and then the dry pellets weight was taken.
Results: The results indicates that, Quercetin at a dose of 20 mg/kg body weight exhibited significant inhibition (P<0.05). The Percent Inhibition with the control, standard (Indomethacin) and the test compound (Quercetin) in the carrageenan induced paw edema model were 0%, 74% and 68% and 0%, 37%, and 34% respectively in cotton pellet induced granuloma method.
Conclusion: This study concludes that, Quercetin have significant anti-inflammatory effects in both acute and chronic inflammatory conditions.

Author(s): Warda Mohamed Kaidama and Rajesh N. Gacche

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