Antihypertensive drug loaded PLGA nanoparticles: Impact of formulation variables on particle size distribution

Carvedilol, an antihypertensive drug is a non-cardioselective beta blocker which is used for the treatment of symptomatic heart failure. Spherical Carvedilol-PLGA nanoparticles with controlled size were designed. Carvedilol, a hydrophilic molecule was entrapped into the nanoparticles with theoretical loading varying from 15- 38 %(w/w).This study investigates the impact of some process variables on the mean diameter and size distribution of nanoparticles prepared by emulsion solvent- evaporation technique. The results shows that sonication time, PLGA content, Surfactant concentration, Aqueous and organic phase ratio and overall the method of solvent evaporation have significant influence on size distribution of the nanoparticles.

Author(s): Sovan Lal Pal, Utpal Jana. G. P. Mohanta and P. K. Manna

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