Antiemetic Activity of Tithonia diversifolia (HEMSL.) A. Gray Leaves in Copper Sulfate Induced Chick Emesis Model

Current study was designed to explore the antiemetic effect of the methanolic extract of Tithonia diversifolia (Hemsl.) A. Gray., leaves using chick emesis model in order to validate their folk use in G.I. disorders. Emesis was induced by the oral administration of copper sulfate 50mg/kg body weight to male chicks of four days age. The antiemetic activity was determined by calculating the mean decrease in number of retching in contrast with those of control. Tithonia diversifolia leaves extract (150 mg/kg orally) showed significant (p < 0.05) antiemetic effect and compared with reference drug chlorpromazine.

Author(s): Salman Ahmed, Patrricia Akpomedaye Onocha

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