Antidiabetic and Wound Healing Activity of Catharanthus roseus L. in Streptozotocin- Induced Diabetic Mice

Ethnopharmacological Relevance: Natural antioxidants due to their radical scavenging and lipid peroxidation ability are considered as possible protection against delayed wound healing in diabetic condition. The Aim of the Study: The objective of our study was to evaluate the antidiabetic and wound healing activity of the leaf extract of Catharanthus roseus L in mice. Materials and Methods: The methanolic extract of leaf of Catharanthus roseus L at a dose of 200 mg/kg and 400 mg/kg body weight was induced through intraperitonial in mice. To create wounds, a single full thickness 1.0 cm diameter superficial excision was made on the mid-dorsum of each mouse. The measurement of the wound diameter was taken on 1, 3, 7 and 10 days by using transparency paper and permanent marker. Results: The plant drugs increased the rate of wound contraction and significantly decrease the glucose level in blood. The results were compared with control group of mice that were kept on only saline water. The wound closure was optimal at the dose of 200 mg/kg body weight. The extract of Catharanthus roseus L significantly increased the wound contraction and formation of collagen fibres in the mice compared with controls (P < 0.001). Conclusion: The methanolic extract of Catharanthus roseus L significantly increases the wound contraction in mice that promises to overcome the delayed wound healing in diabetic condition.

Author(s): Anurag Singh, Pramod Kumar Singh and Rakesh Kumar Singh

Abstract | PDF

Share This Article