Antidiabetic activity of Madhumega Churanam (Siddha formulation) in alloxan induced diabetic rats

The present study was performed to evaluate Siddha formulation for its antidiabetic activity in alloxan (120 mg/kg, i.p.) induced diabetic rats. The effects of Siddha formulation on fasting blood glucose level, body weight, fluid intake cholesterol and triglyceride were studied. Siddha formulation (100 mg/kg/day and 200 mg/kg/day p.o.) was administered to a group of diabetic rats (n=6) for 14 consecutive days and the observed data was compared with glibenclamide (10 mg/ kg/ day p.o.). Administration of churanam causes a significant reduction of blood glucose level (p< 0.001), body weight (p<0.001), fluid intake levels (p<0.001), cholesterol (p<0.001) and triglycerides (p<0.001), vs diabetic control. It can be concluded from the present study that oral administration of Siddha formulation (Madhumega churanam) ameliorated the plasma glucose and lipid levels in alloxan- induced diabetic rats.

Author(s): Vadivelan R, Umasankar P, Dipanjan M, Dhanabal S.P, Shanish A, Satishkumar M.N and Elanko K

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