Anticancerous and antiproliferative/cytotoxic activity of curcuma pseudomontana (hill turmeric) collected from the sub Himalayan region of Uttrakhand, India

In this study we determineanticancerous and cytotoxic/antiproliferative activity of Curcuma pseudomontana. The tuber with rhizomes of Curcuma pseudomontanawere collected, shade dried and then extracted with distill water, methanol and ethanol using soxhlet extraction procedure. Anticancer activity of different plant samples is determined by cytopathic effect of plant extract on BHk-21 cell line, antiproliferative and cytotoxic activity is determined by using MTT assay against BHK-21 cell line. From this study we determine that the active phytocompounds inhibit the growth of BHK-21 cell line, this is confirmed after cytopathic effect determination. Between 2-20 mg is IC50 value of plant extract for BHK-21 cell line; at this concentration 50% cells are died. Observations show that antiproliferative/cytotoxic activity of all extractsincreases with increasing the concentration of plant extract.

Author(s): Shivani Kandwal, Deepika Kanan, Deepak Som and Vinod Singh Bisht*

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