Antibacterial effect of Azadirachta indica (CN: Neem or Dongo Yaro) parts on some urinary tract bacterial isolates

Several scientific findings have attached various biological activities of clinical significance on several wonder plants that are indigenous to Africa. Hence, this study investigates the antimicrobial activity of leaves and back extracts of Azadirachta indica (Dongo yaro) on human urinary tract bacteria isolates. Following standard laboratory procedures, the leaves and back extracts of Azadirachta indica were studied on Gram positive bacteria (Staphylococcus aureus) and two strains of Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). The results showed that the degree of antibiotic potentials varies with the extraction solvents (water, ethanol, 1% HCl, acetone and petroleum ether). Comparatively, petroleum ether extract of leave and bark of Azadirachta indica were more potent against the urinary tract bacterial isolates, however, there was no different in the parts of Azadirachta indica used expect for the water extract where the bark extract was more potent than the leave. The differences in MIC between extraction solvents and that of the standard drugs (perflacine; 4.0 mg/ml, and cefuroxime; 6.0 mg/ml) were significant differences (p<0.05) from those of Azadirachta indica leave and bark extracts. Judging by the findings of this study, leave and bark extracts of Azadirachta indica demonstrated antibacterial potential against gram positive and negative bacteria and as such could be a source of antibiotic.

Author(s): Orhue P.O*, Momoh A.R.M, Igumbor E.O and Esumeh F.I

Abstract | PDF

Share This Article