ISSN : 2575-7725
Late prenatal growth, early postnatal growth, and layering of the neocortical neurons (NC-Ns) playdetermining roles in the development of the cerebral cortex (CC). Here, we systematically explore theinteractive role of neuronal surface receptors (NSRs) on cytoskeleton activation (CA) and thepiconewton (pN) force generation (P-FG) and their influence on the proper development, growth,and functioning of neurons using a designed DNA nanomechanical device (DNA-NMD).This DNA-NMD, functioning as a molecular tension probe (MTP), can be used to selectively bind the different NSRs (β-NGFR, Reelin, and Integrin) to mono-, bi-, and trispecifically activate the receptors on the NC-Ns surface for imaging and calculating the P-FG involved in variousprocesses. Measurements in vivo on the brain of newly born Institute of Cancer Research mice(early postnatal)
Journal of Stem Cell Biology and Transplantation received 80 citations as per Google Scholar report