Anthelmintic and Antiproliferative activity of aerial parts of Persicaria hydropiper

A study was conducted to investigate aerial parts of Persicaria hydropiper (P.hydropiper) as an effective remedy for gastrointestinal helminthes and proliferative disease. In vitro anthelmintic activity was carried out against Pheretima posthuma. The parameters like: time of paralysis and time of death were determined by using the extract at the concentrations of 10, 25 and 50 mg/ml. The extract exhibited significant anthelmintic activity at highest concentration of 50 mg/ml as compared with piperazine citrate (10 mg/ml) as standard reference and distilled water as control. In vivo antiproliferative activity of the same extract at the dose of 30, 40 and 50 mg/kg/day (i.p.) were evaluated against Ehrlich Ascites Carcinoma (EAC) cells in Swiss albino mice. Experimental parameters like tumor cell count, mean survival time and life span enhancement were evaluated to assess antiproliferative activity. We found that the extract at the dose of 50 mg/kg/day (i.p) significantly (P<0.05) decreases tumor weight, increases life span and reduces tumor cell growth rate in comparison to those of EAC bearing mice receiving no extract (negative control) in a dose-dependant manner.

Author(s): Md. Obayed Raihan1, Md. Khalequeuzzaman, Afrina Brishti, Syed Mohammed Tareq, Aslam Hossain, Sohel Rana.

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