The Congenital heart defects present in humans and a common mortality anomaly. It is (8-10/1000 births). The main reason is supposed to be multifactorial influences including environmental and genetic components and common Syndrome forms. In this we will briefly discuss about few of the causes that are responsible for the Congenital Heart Defects (CHDs), such as the 22q11.2 deletion, Disturbances in left-right patterning, Mutation in GDF1 gene, Maternal Obesity and SSRIs usage in maternity.