An Improved Synthesis of Telmisartan: An Antihypertensive Drug

Srinivas Ambati; Hanumantha Rao Penikelapati; T V Maruthikumar; Nidichenametla Sreenivasan; Narahari Babu Ambati

Abstract

An Improved Synthesis of Telmisartan: An Antihypertensive Drug

An improved synthesis of the angiotensin II receptor antagonist telmisartan is described. It involves Suzuki coupling of 4-formylphenylboronic acid with 2-(2-bromophenyl)-4,4-dimethyl-2- oxazoline followed by construction of benzimidazole moiety regioselectively though a reductive amination-condensation sequence, replacing the earlier alkylation of the preformed benzimidazole route. This methodology overcomes many drawbacks of the reported syntheses.

Author(s): Srinivas Ambati, Hanumantha Rao Penikelapati, T V Maruthikumar, Nidichenametla Sreenivasan and Narahari Babu Ambati

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