An efficient and simple un-catalysed synthesis of 1,4-dihydropyridines in an
aqueous media

Sangita S. Makone; S; eep N. Niwadange

Abstract

An efficient and simple un-catalysed synthesis of 1,4-dihydropyridines in an aqueous media

An efficient, un-catalysed and green method for the synthesis of 1,4-dihydropyridine derivatives in an aqueous media under reflux condition through a three component one pot condensation process of aldehyde, b- dicarbonylcompounds and liquid ammonia has been developed. This procedure offers several advantages including high yields, environmentally benign solvent and simple work up process

Author(s): Sangita S. Makone and Sandeep N. Niwadange

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