Acute Toxicity and Genotoxic Activity of Hibiscus rosa sinensis Flower Extract

The use of herbal extracts requires toxicological and genotoxic evaluations to establish and verify safety before being added to human cosmetic, pharmaceutical medicine, or alimentary products. Hibiscus rosa sinensis flowers have been used in traditional medicine as treatment for several diseases. In this work, the methanolic flower extract of hibiscus rosa sinensis was evaluated with respect to its genotoxic potential through micronucleus assay in Balb/c mice. The frequency of micronuclei in groups of animals treated with hibiscus rosa sinensis showed no differences as compared to the negative control (vehicle); therefore, it is considered that the hibiscus rosa sinensis showed no genotoxic activity in the micronucleus test.

Author(s): Anil Kumar Meena, Akansha Jain, Keerti Pandey and R. K. Singh

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