A Study to Investigate the Ability of the Fungus (Penicillium italicum) to Produce Lovastatin Compound and Test the Effectiveness of Fermented Product in Inhibiting the Growth of Isolation of the Fungus (Aspergillus fumigatus)

This study was carried out to investigate a possibility of the fungus (Penicillium italicum) to produce lovastatin compound by using a Solid Substrate Fermentation method (SSF) and rice powder as a substrate in it, and also to test the effectiveness of the SSF product with concentrations of (0.25, 0.5, 1, 2) mg/ml in inhibiting the growth of isolation of the fungus (Aspergillus fumigatus). The analysis of the SSF product by using ATR-FTIR showed presence several peaks belong to functional groups contain in lovastatin compound such as (alcohol O-H, C-H, C-O-H, and C-O-C). The study showed that the efficacy of SSF product in inhibiting the growth of studied fungus varied according to concentration compared to control, where the highest rate of inhibition reached 79% at concentration 2 mg/ml.

Author(s): Amjad Deeb*, Nawal Ali, Hajar Nasser and Reem Salame

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