A Study of Cancer Cell Mechanics Using 3D Finite Element Modelling

Using finite element modelling, a robust computer model of a cancer cell is shown. The model accurately reflects the nuances of the numerous cellular substructure components. The impact of cytoskeleton deterioration on the cancer cell's overall elastic characteristics is discussed. The fact that many anti-cancer medications disrupt the intrinsic mechanics of the cytoskeleton as therapeutic therapies for the eradication of cancer tumours is the motivation for deteriorated cancer cellular substructure, the cytoskeleton. The cytoskeleton (CSK) is a cell's most important mechanical component. Furthermore, parameter investigations revealed that the material properties of the continuum (thickness and elasticity) have a substantial influence on the overall cellular stiffness, but Poisson's ratio has a lesser influence. The proposed FEM models may be used to quantify the contribution of main cell components to overall cellular stiffness, as well as to gain insight into how cells respond to external mechanical stimuli and explore the underlying mechanical mechanisms and cell biomechanics.

Author(s): Welling Mihir

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