A spectrophotometric method for the determination of demeclocycline and zirconium (IV)

Analytical determination of Demeclocyline (DMC) and Zirconium (IV) in pharmaceutical formulation is carried and based on a colour reaction between DMC and Zirconium (IV) forms yellow coloured complex with DMC in a buffer of PH-6. The method can be conveniently used for the determination of Zirconium IV) and DMC in the ranges of 0.95 to 7.35 mg/ml. and 0.004 to 0.040 mg/ml respectively. The method is successfully applied for the determination of DMC in pharmaceutical formulation. Effect of various parameters in his pH, metal ion concentration, drug concentration, of vary solvents is studied. The optimum condition are observed for the determination of zirconium and the drug

Author(s): T. R. Kishore1, T. R. Krishna2 and V. Suryanarayana Rao3

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