A matched case-control study to assess the association of Chikungunya severity among blood groups and other determinants in Tesseney, Gash Barka zone, Eritrea

Abstract
Objectives: A total of 1074 suspected chikungunya cases were reported in Tesseney Province, Gash Barka region, Eritrea during an outbreak. This study was aimed to assess the possible association of chikungunya severity among ABO blood groups and other potential determinants.
Methods: A sex-matched and age-matched casecontrol study was conducted during the outbreak. For each case, one control subject had been selected from the mild Chikungunya cases and a second control subject had also been designated from neighbourhood of cases, were analysed, scrutinized and appeared to scheme of comparison. This study was pursuit from October 15, 2018 to November 15, 2018. Calculating odds ratios (ORs) and conditional (fixed-effect) logistic regression methods were being applied.
Results: In this outbreak, 137 severe suspected chikungunya cases and 137 mild chikungunya suspected patients and 137 controls free of chikungunya from the neighbourhood of cases were analysed. Non-O individuals compared to those with O blood group indicated as significant with p value of 0.002 and a strong association of chikungunya severity was found with hypertension and diabetes (p-value of <0.0001); whereas, there was no association between chikungunya severity and asthma with p-value of 0.695 and also no association with pregnancy (p-value =0.881), ventilator (p-value =0.181) ,air conditioner (p-value = 0.247), and didn’t use latrine and pit latrine (value = 0.318).
Conclusions: Prioritization is recommended for patients with chronic diseases and non-O blood group since they are found to be susceptible to severe chikungunya disease. Identification of human cell surface receptor(s) for CHIKV is quite necessary for further understanding of its pathophysiology in humans. Therefore, Molecular and functional studies will necessarily be helpful in disclosing the association of blood group antigens
and CHIKV infections.
Keywords: Chikungunya, Chikungunya virus, Disease outbreaks, Case-control studies, Eritrea.
Biography: Mr. Samsom Mehari Giliu is proficient Public Health Officer since 2015 hitherto now. Mr. Samsom is Chief Manager of Regional TB/leprosy control program Division of CDC Department, Ministry of Health, Anseba Region, Eritrea. It is good to mention that 42 health facilities expedite their daily activities concerning TB and Leprosy under his supervision. He is responsible for providing training, reporting to the national and conducting seminars, supervisions advocacy, and creating awareness on TB, Leprosy and HIV/AIDS in Zoba Anseba, which is one of the six Eritrean administrative zones. He is also Member of regional TB, HIV and Diabetic Committee and one of the three members of zonal research committee. He is also a member of regional epidemic response team. He got his B.Sc. in public health from School of public health, Asmara College of health science, Asmara, Eritrea. And now he is doing his Masters in Clinical Trial in Addis Ababa University. Mr. Samsom is a young researcher, who has insatiable enthusiasm for research. He has published three articles so far with limited resource.
Samsom Mehari Giliu
Eritrean Public health Association
Diversified interest from infectious disease to noncommunicable to health promotion. There is no funding source
Recent Publications
Samsom M Giliu et al, FACTORS ASSOCIATED WITH OBSTETRIC FISTULA AMONG WOMEN ADMITTED TO MENDEFERA NATIONAL FISTULA CENTER, ERITREA:
International Journal of Recent Scientific Research Vol. 9, Issue, 3(G), pp. 25097-25100, March, 2018:
Samsom Mehari, Gabriel Dawit, HONEY A BOOSTER FOR THE ACTIVITY OF ANTIBIOTICS: Int J Pharm 2017; 7(3): 196-200, CODEN: IJPNL6:
Samsom Mehari Giliu et al, ASSESSMENT OF HEALTH EDUCATION TALKS IN HEALTH FACILITIES OF REGION ANSEBA-ERITREA: Volume 8; Issue 01(B); January 2019 Page No.16821-16824.

Author(s): Samsom Mehari Giliu

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