A facile synthesis and antimicrobial activity of some new 2-subsituted benzimidazole derivatives carrying pyridine

Some new 2-amino-6-(1H-benzimidazol -2-yl)-4- phenyl pyridine -3- carbonitriles have been synthesized and evaluated for antimicrobial activity. 2-Acetyl Benzimidazoles (1) were reacted with appropriately substituted benzaldehydes (2) in presence of ethanol to furnish substituted chalcones (3a-f). These chalcones were further treated with Malononitrile & Ammonium Acetate to afford substituted 2-amino-6-(1H-benzimidazol -2-yl)-4- phenyl pyridine -3- carbonitriles (4a-f). The structure of newly synthesized compounds (4a-f) has been confirmed on the basis of spectral data and elemental analysis. All the compounds were screened for their antibacterial activity against K. pneumonae, B. subtilis, E. coli and P. pseudomonas and for antifungal activity against C. albicans and A. niger. The compounds exhibited good antibacterial and moderate antifungal activities

Author(s): Janardan S. Yadav and Yogendra K. Srivastava

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