The cholera is characterized as an acute intestinal transmission disease caused by the Cholera vibrio bacterium. The V.Cholera can be gram negative bacterium that is toxin (CT) classified in projects rather 200. Despite this number, only the six couonions O1 and O139 cause cholera epidemics. V. Cholera O1 has two biotypes: the classic and its. The Biotype of the Tor is a smaller pathogen than the classic biotype, causing more asymptomatic infections. Furthermore, it is greater resistance to external conditions.