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The main objective of the present work was to develop sustained release matrix tablets of quetiapine fumarate using different polymers viz. Hydroxy propyl methyl cellulose (HPMC) and PVP K30. Varying ratios of drug and polymer like were selected for the study. After fixing the ratio of drug and polymer for control the release of drug up to desired time, the release rates were modulated by combination of two different rates controlling material and triple mixture of two different rate controlling material. After evaluation of physical properties of tablet, the in vitro release study was performed in 0.1 N HCl pH 1.2 for 2 hrs and in phosphate buffer pH 6.8 up to 12 hrs. The effect of polymer concentration and polymer blend concentration were studied. Dissolution data was analysed by Higuchi expression. It was observed that matrix tablets contained polymer blend of HPMC/PVP K30 were successfully sustained the release of drug up to 12 hrs. Among all the formulations, formulation QFSRT/08 which contains 60% HPMC K15M and 06% of PVP K30 release the drug which follow Higuchi kinetics via, swelling, diffusion and erosion and the release profile of formulation QFSRT/08 was comparable with the prepared batch products. Stability studies (40±2ºC/75±5%RH) for 6 months indicated that quetiapine fumarate was stable in the matrix tablets. The DSC and FTIR study revealed that there was no chemical interaction between drug and excipients.

Author(s): Deepak Sahu and  Rana A. C.

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